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pentobarbital will decrease the level or outcome of estropipate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.pentobarbital will minimize the extent or impact of fentanyl intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Intently. Coadministration of fentanyl with CYP3A4